منابع مشابه
Homicide, fragile X syndrome, and mental retardation.
Persons with mental retardation represent 1 to 2% of the worldwide population. Due to their suggestive behavior and ingenuousness, these persons tend to be vulnerable to violence in all its forms. Nevertheless, difficulties concerning impulse control and lack of judgment contribute to disruptive and maladaptive behaviors in some of them. These misbehaviors may include sexual violence, thefts, p...
متن کاملFragile X mental retardation syndrome: structure of the KH1-KH2 domains of fragile X mental retardation protein.
Fragile X syndrome is the most common form of inherited mental retardation in humans, with an estimated prevalence of about 1 in 4000 males. Although several observations indicate that the absence of functional Fragile X Mental Retardation Protein (FMRP) is the underlying basis of Fragile X syndrome, the structure and function of FMRP are currently unknown. Here, we present an X-ray crystal str...
متن کاملX inactivation of the FMR1 fragile X mental retardation gene.
X chromosome inactivation has been hypothesised to play a role in the aetiology and clinical expression of the fragile X syndrome. The identification of the FMR1 gene involved in fragile X syndrome allows testing of the assumption that the fragile X locus is normally subject to X inactivation. We studied the expression of the FMR1 gene from inactive X chromosomes by reverse transcription of RNA...
متن کاملFragile X mental retardation protein: from autism to neurodegenerative disease
INTRODUCTION Fragile X mental retardation protein (FMRP) is a RNA binding protein, the absence of which due to silencing of the FMR1 gene causes fragile X syndrome, an X-linked neurodevelopmental disorder (Bassell and Warren, 2008; Bhakar et al., 2012; Santoro et al., 2012). FMRP regulates the transport, stability and translation of its mRNA targets. Loss of FMRP alters translational control an...
متن کاملThe microRNA pathway and fragile X mental retardation protein.
Fragile X syndrome, one of the most common forms of inherited mental retardation, is caused by the functional loss of fragile X mental retardation protein (FMRP). MicroRNAs (miRNAs), a newly discovered class of small noncoding RNAs, have been implicated in multiple biological processes through posttranscriptional gene regulation. Recent evidence supports this view in terms of the biochemical an...
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ژورنال
عنوان ژورنال: Archives of Disease in Childhood
سال: 1990
ISSN: 0003-9888,1468-2044
DOI: 10.1136/adc.65.3.335-d